ABSTRACT
The charts of 58 patients with squamous-cell carcinomas of the lower lip, treated at the General Hospital of the University of Sao Paulo Medical School from January 1980 to December 1989, were retrospectively analyzed. In addition to regular demographic data, all available information was collected regarding: smoking and drinking habits; sun exposure; clinical stage; macroscopic features of the primary lesions; type of treatment; and follow-up. A meticulous pathological analysis, comprising the histologic differentiation grade, maximal tumor thickness, sun elastosis, perineural spread, vascular and muscular invasion, surgical margins, peritumoral inflammatory infiltrate, and positive lymph nodes, with or without extracapsular spread, was undertaken as well. The evaluation of the overall 5-year survival showed significant statistical differences, with prognostic implications, for the following variables: maximal tumor thickness, T-stage and positive nodes.
Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Lip Neoplasms/pathology , Carcinoma, Squamous Cell/pathology , Aged, 80 and over , Lip Neoplasms/surgery , Retrospective Studies , Follow-Up Studies , Survival Analysis , Carcinoma, Squamous Cell/surgery , Lymphatic Metastasis , PrognosisABSTRACT
Análise retrospectiva de 58 prontuários de portadores de carcinoma espinocelular do lábio inferior, atendidos no período de janeiro de 1980 a dezembro de 1989, no Hospital das Clínicas da Faculdade de Medicina da Universidade de Säo Paulo. Além dos dados demográficos, foram considerados o uso de álcool, fumo e a exposiçäo solar, assim como o estado clínico na época da cirurgia, as características macroscópicas dos tumores, o tipo de tratamento instituído e as observaçöes do seguimento pós-operatório. Os espécimens cirúrgicos foram submetidos a minuciosa revisäo anátomo-patológica com análise do grau de diferenciaçäo histológica, espessura máxima tumoral, elastose solar, invasöes perineural, vascular e muscular, margens cirúrgicas, infiltrado inflamatório peritumoral e acometimento glanglionar, com ou sem rotura capsular. A análise da sobrevida global em 5 anos demonstrou valor prognóstico significativo para as seguintes variáveis: espessura tumoral, tamanho da neoplasia (T) e acometimento ganglionar